Ductal carcinoma in situ DCIS is non-invasive breast cancer. Ductal means that the cancer starts inside the milk ducts, carcinoma refers to any cancer that begins in the skin or other tissues including breast tissue that cover or line the internal organs, and in situ means "in its original place. When you have had DCIS, you are at higher risk for the cancer coming back or for developing a new breast cancer than a person who has never had breast cancer before. Most recurrences happen within the 5 to 10 years after initial diagnosis. Learn what additional steps you can take to lower your risk of a new breast cancer diagnosis or a recurrence in the Lower Your Risk section. If breast cancer does come back after earlier DCIS treatment, the recurrence is non-invasive DCIS again about half the time and invasive about half the time.
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GEO help: Mouse over screen elements for information. Not logged in Login. Series GSE Molecular diversity in ductal carcinoma in situ DCIS and early invasive breast cancer. Homo sapiens. Ductal carcinoma in situ DCIS is a non-invasive form of breast cancer where cells restricted to the ducts exhibit an atypical phenotype.
We studied gene expression patterns of 31 pure DCIS, 36 pure invasive cancers and 42 cases of mixed diagnosis invasive cancer with an in situ component using Agilent Whole Human Genome Oligo Microarrays 44k. Six normal breast tissue samples were also included as controls.
All DCIS and invasive samples could be classified into the intrinsic molecular subtypes defined for invasive breast cancer. Hierarchical clustering establishes that samples group by intrinsic subtype, and not by diagnosis. We observed heterogeneity in the transcriptomes among DCIS of high histological grade and identified a distinct subgroup containing seven of the 31 DCIS samples with gene expression characteristics more similar to advanced tumours.
A set of genes independent of grade, ER-status and HER2-status was identified by logistic regression that univariately classified a sample as belonging to this distinct DCIS subgroup.
The genes that differentiate between these two types of DCIS suggest several processes related to the re-organisation of the microenvironment. This raises interesting possibilities for identification of DCIS lesions both with and without invasive characteristics, which potentially could be used in clinical assessment of a woman's risk of progression, and lead to improved management that would avoid the current over- and under-treatment of patients.
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Treatment of Ductal Carcinoma in Situ (DCIS)
GEO help: Mouse over screen elements for information. Not logged in Login. Series GSE Molecular diversity in ductal carcinoma in situ DCIS and early invasive breast cancer.
New Cancer Model Shows Genomic Link Between DCIS and IDC Breast Cancer Types
Each breast contains 15 to 20 lobes of glandular tissue, arranged like the petals of a daisy. The lobes are further divided into smaller lobules that produce milk for breast-feeding. Small tubes ducts conduct the milk to a reservoir that lies just beneath your nipple. Ductal carcinoma in situ DCIS is the presence of abnormal cells inside a milk duct in the breast.
Ductal Carcinoma In Situ (DCIS)