The antifibrogenic effect of etanercept on development of liver cirrhosis induced by thioacetamide in rats. Ultrastruct Pathol ; 41 1 : , Liver cirrhosis is an elevating cause of morbidity and mortality worldwide. Sixty male albino rats Rattus norvegicus were equally randomized into three groups. Group I served as the control.

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Sorry, but Javascript is not enabled in your browser! How to cite. MARC format. OAI DC format. Master's Dissertation. Experimental and Comparative Pathology. Morphometric evaluation of hepatic hemosiderosis and necrosis in Magellanic penguins Spheniscus magellanicus naturally infected by Plasmodium spp.

Avian malaria Hemosiderin Iron Liver Rehabilitation. While under care, these birds may develop avian malaria, a mosquito-transmitted disease caused by protozoans of the genus Plasmodium. Hepatic hemosiderosis and necrosis have been previously described in avian malaria. We used morphometric techniques to evaluate hemosiderosis and necrosis in Perls- and reticulin-stained liver samples from 24 Magellanic penguins naturally infected by Plasmodium spp.

All birds were kept under similar housing and husbandry regimens. Our goal was to evaluate the significance of hepatic hemosiderosis and necrosis in Magellanic penguins infected with Plasmodium sp. Histological sections were analyzed under a microscope equipped with a digital system for image analysis. The percentage of the area occupied by hemosiderin and reticular fibers were respectively considered the index of hepatic hemosiderosis IHH and index of hepatic necrosis IHN.

Hepatic hemosiderosis was possibly related to other causes, such as seasonal physiological changes, anthropogenic disturbance and climatic changes leading to starvation, and husbandry and iron supplementation while under care. Hepatic necrosis was significant between both groups, suggesting a possible relationship between this pathology and Plasmodium spp. Avian malaria is one of the most important diseases of captive penguins, and may seriously compromise the rehabilitation of Magellanic penguins.

Further studies are still needed to clarify the mechanisms of these hypotheses. Linhagens de Plasmodium spp. WARNING - Viewing this document is conditioned on your acceptance of the following terms of use: This document is only for private use for research and teaching activities. Reproduction for commercial use is forbidden.

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We report a case of a 63 year old male patient with history of chronic hepatopathy with cirrhosis. During his medical control and last hospitalization no cirrhosis etiology was found. On autopsy, excess iron was found with histochemical stains in liver, pancreas, myocardium and gastric mucosa. These findings, along with the clinical history and laboratory tests, showed that the origin of cirrhosis was primary hemochromatosis. Hepatic cirrosis , primary and secondary hemochromatosis , hemosiderosis , HME gene, transferrin , ferritin , serum iron, bronzed diabetes. Churchill Livingstone. USA : Elsevier.


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